RapamycinFungusV1, Main, Exploration, bibRecord, 000983

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.

Identifieur interne : 000983 ( Main/Exploration ); précédent : 000982; suivant : 000984

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.

Auteurs : Said Izreig [Canada] ; Bozena Samborska [Canada] ; Radia M. Johnson [Canada] ; Alexey Sergushichev [États-Unis] ; Eric H. Ma [Canada] ; Carine Lussier [Canada] ; Ekaterina Loginicheva [États-Unis] ; Ariel O. Donayo [Canada] ; Maya C. Poffenberger [Canada] ; Selena M. Sagan [Canada] ; Emma E. Vincent [Canada] ; Maxim N. Artyomov [États-Unis] ; Thomas F. Duchaine [Canada] ; Russell G. Jones [Canada]

Source :

Cell reports [ 2211-1247 ] ; 2016.

RBID : pubmed:27498867

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Base Sequence (MeSH), Cell Line, Tumor (MeSH), Cell Transformation, Neoplastic (genetics), Cell Transformation, Neoplastic (metabolism), Cell Transformation, Neoplastic (pathology), Gene Expression Regulation, Neoplastic (MeSH), Glycolysis (genetics), Heterografts (MeSH), Humans (MeSH), Lymphocyte Transfusion (MeSH), Lymphocytes (metabolism), Lymphocytes (pathology), Lymphoma (genetics), Lymphoma (metabolism), Lymphoma (pathology), Mechanistic Target of Rapamycin Complex 1 (MeSH), Mice (MeSH), MicroRNAs (genetics), MicroRNAs (metabolism), Multiprotein Complexes (genetics), Multiprotein Complexes (metabolism), Oxidative Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Proto-Oncogene Proteins c-myc (genetics), Proto-Oncogene Proteins c-myc (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , genetics : MicroRNAs, Multiprotein Complexes, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-myc, TOR Serine-Threonine Kinases.
- chemical , metabolism : MicroRNAs, Multiprotein Complexes, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-myc, TOR Serine-Threonine Kinases.
- chemical : Mechanistic Target of Rapamycin Complex 1.
- genetics : Cell Transformation, Neoplastic, Glycolysis, Lymphoma.
- metabolism : Cell Transformation, Neoplastic, Lymphocytes, Lymphoma.
- pathology : Cell Transformation, Neoplastic, Lymphocytes, Lymphoma.
- Animals, Base Sequence, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Heterografts, Humans, Lymphocyte Transfusion, Mice, Oxidative Phosphorylation, Signal Transduction.

Abstract

A central hallmark of cancer cells is the reprogramming of cellular metabolism to meet the bioenergetic and biosynthetic demands of malignant growth. Here, we report that the miR-17∼92 microRNA (miRNA) cluster is an oncogenic driver of tumor metabolic reprogramming. Loss of miR-17∼92 in Myc(+) tumor cells leads to a global decrease in tumor cell metabolism, affecting both glycolytic and mitochondrial metabolism, whereas increased miR-17∼92 expression is sufficient to drive increased nutrient usage by tumor cells. We mapped the metabolic control element of miR-17∼92 to the miR-17 seed family, which influences cellular metabolism and mammalian target of rapamycin complex 1 (mTORC1) signaling through negative regulation of the LKB1 tumor suppressor. miR-17-dependent tuning of LKB1 levels regulates both the metabolic potential of Myc(+) lymphomas and tumor growth in vivo. Our results establish metabolic reprogramming as a central function of the oncogenic miR-17∼92 miRNA cluster that drives the progression of MYC-dependent tumors.

DOI: 10.1016/j.celrep.2016.07.036
PubMed: 27498867

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Donayo, Ariel O" sort="Donayo, Ariel O" uniqKey="Donayo A" first="Ariel O" last="Donayo">Ariel O. Donayo</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.</title>
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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Samborska, Bozena" sort="Samborska, Bozena" uniqKey="Samborska B" first="Bozena" last="Samborska">Bozena Samborska</name>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
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<author><name sortKey="Johnson, Radia M" sort="Johnson, Radia M" uniqKey="Johnson R" first="Radia M" last="Johnson">Radia M. Johnson</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
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<author><name sortKey="Sergushichev, Alexey" sort="Sergushichev, Alexey" uniqKey="Sergushichev A" first="Alexey" last="Sergushichev">Alexey Sergushichev</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>ITMO University, St. Petersburg 197101, Russia; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
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<author><name sortKey="Ma, Eric H" sort="Ma, Eric H" uniqKey="Ma E" first="Eric H" last="Ma">Eric H. Ma</name>
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<country xml:lang="fr">Canada</country>
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<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
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<author><name sortKey="Lussier, Carine" sort="Lussier, Carine" uniqKey="Lussier C" first="Carine" last="Lussier">Carine Lussier</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Loginicheva, Ekaterina" sort="Loginicheva, Ekaterina" uniqKey="Loginicheva E" first="Ekaterina" last="Loginicheva">Ekaterina Loginicheva</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">Université Washington de Saint-Louis</orgName>
</affiliation>
</author>
<author><name sortKey="Donayo, Ariel O" sort="Donayo, Ariel O" uniqKey="Donayo A" first="Ariel O" last="Donayo">Ariel O. Donayo</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poffenberger, Maya C" sort="Poffenberger, Maya C" uniqKey="Poffenberger M" first="Maya C" last="Poffenberger">Maya C. Poffenberger</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sagan, Selena M" sort="Sagan, Selena M" uniqKey="Sagan S" first="Selena M" last="Sagan">Selena M. Sagan</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vincent, Emma E" sort="Vincent, Emma E" uniqKey="Vincent E" first="Emma E" last="Vincent">Emma E. Vincent</name>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Artyomov, Maxim N" sort="Artyomov, Maxim N" uniqKey="Artyomov M" first="Maxim N" last="Artyomov">Maxim N. Artyomov</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">Université Washington de Saint-Louis</orgName>
</affiliation>
</author>
<author><name sortKey="Duchaine, Thomas F" sort="Duchaine, Thomas F" uniqKey="Duchaine T" first="Thomas F" last="Duchaine">Thomas F. Duchaine</name>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Russell G" sort="Jones, Russell G" uniqKey="Jones R" first="Russell G" last="Jones">Russell G. Jones</name>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: russell.jones@mcgill.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell reports</title>
<idno type="eISSN">2211-1247</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Base Sequence (MeSH)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Cell Transformation, Neoplastic (genetics)</term>
<term>Cell Transformation, Neoplastic (metabolism)</term>
<term>Cell Transformation, Neoplastic (pathology)</term>
<term>Gene Expression Regulation, Neoplastic (MeSH)</term>
<term>Glycolysis (genetics)</term>
<term>Heterografts (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lymphocyte Transfusion (MeSH)</term>
<term>Lymphocytes (metabolism)</term>
<term>Lymphocytes (pathology)</term>
<term>Lymphoma (genetics)</term>
<term>Lymphoma (metabolism)</term>
<term>Lymphoma (pathology)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term>
<term>Mice (MeSH)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (metabolism)</term>
<term>Multiprotein Complexes (genetics)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Oxidative Phosphorylation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Proto-Oncogene Proteins c-myc (genetics)</term>
<term>Proto-Oncogene Proteins c-myc (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (génétique)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Glycolyse (génétique)</term>
<term>Humains (MeSH)</term>
<term>Hétérogreffes (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Lymphocytes (anatomopathologie)</term>
<term>Lymphocytes (métabolisme)</term>
<term>Lymphomes (anatomopathologie)</term>
<term>Lymphomes (génétique)</term>
<term>Lymphomes (métabolisme)</term>
<term>Phosphorylation oxydative (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines proto-oncogènes c-myc (génétique)</term>
<term>Protéines proto-oncogènes c-myc (métabolisme)</term>
<term>Régulation de l'expression des gènes tumoraux (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Séquence nucléotidique (MeSH)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
<term>Transformation cellulaire néoplasique (anatomopathologie)</term>
<term>Transformation cellulaire néoplasique (génétique)</term>
<term>Transformation cellulaire néoplasique (métabolisme)</term>
<term>Transfusion de lymphocytes (MeSH)</term>
<term>microARN (génétique)</term>
<term>microARN (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term>
<term>Multiprotein Complexes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Proto-Oncogene Proteins c-myc</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>MicroRNAs</term>
<term>Multiprotein Complexes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Proto-Oncogene Proteins c-myc</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes</term>
<term>Lymphomes</term>
<term>Transformation cellulaire néoplasique</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Glycolysis</term>
<term>Lymphoma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Glycolyse</term>
<term>Lymphomes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines proto-oncogènes c-myc</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transformation cellulaire néoplasique</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Lymphocytes</term>
<term>Lymphoma</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Lymphocytes</term>
<term>Lymphomes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines proto-oncogènes c-myc</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transformation cellulaire néoplasique</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Lymphocytes</term>
<term>Lymphoma</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Cell Line, Tumor</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Heterografts</term>
<term>Humans</term>
<term>Lymphocyte Transfusion</term>
<term>Mice</term>
<term>Oxidative Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Humains</term>
<term>Hétérogreffes</term>
<term>Lignée cellulaire tumorale</term>
<term>Phosphorylation oxydative</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Souris</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal</term>
<term>Transfusion de lymphocytes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A central hallmark of cancer cells is the reprogramming of cellular metabolism to meet the bioenergetic and biosynthetic demands of malignant growth. Here, we report that the miR-17∼92 microRNA (miRNA) cluster is an oncogenic driver of tumor metabolic reprogramming. Loss of miR-17∼92 in Myc(+) tumor cells leads to a global decrease in tumor cell metabolism, affecting both glycolytic and mitochondrial metabolism, whereas increased miR-17∼92 expression is sufficient to drive increased nutrient usage by tumor cells. We mapped the metabolic control element of miR-17∼92 to the miR-17 seed family, which influences cellular metabolism and mammalian target of rapamycin complex 1 (mTORC1) signaling through negative regulation of the LKB1 tumor suppressor. miR-17-dependent tuning of LKB1 levels regulates both the metabolic potential of Myc(+) lymphomas and tumor growth in vivo. Our results establish metabolic reprogramming as a central function of the oncogenic miR-17∼92 miRNA cluster that drives the progression of MYC-dependent tumors.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27498867</PMID>
<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-1247</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<Issue>7</Issue>
<PubDate><Year>2016</Year>
<Month>08</Month>
<Day>16</Day>
</PubDate>
</JournalIssue>
<Title>Cell reports</Title>
<ISOAbbreviation>Cell Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.</ArticleTitle>
<Pagination><MedlinePgn>1915-28</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.celrep.2016.07.036</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S2211-1247(16)30954-8</ELocationID>
<Abstract><AbstractText>A central hallmark of cancer cells is the reprogramming of cellular metabolism to meet the bioenergetic and biosynthetic demands of malignant growth. Here, we report that the miR-17∼92 microRNA (miRNA) cluster is an oncogenic driver of tumor metabolic reprogramming. Loss of miR-17∼92 in Myc(+) tumor cells leads to a global decrease in tumor cell metabolism, affecting both glycolytic and mitochondrial metabolism, whereas increased miR-17∼92 expression is sufficient to drive increased nutrient usage by tumor cells. We mapped the metabolic control element of miR-17∼92 to the miR-17 seed family, which influences cellular metabolism and mammalian target of rapamycin complex 1 (mTORC1) signaling through negative regulation of the LKB1 tumor suppressor. miR-17-dependent tuning of LKB1 levels regulates both the metabolic potential of Myc(+) lymphomas and tumor growth in vivo. Our results establish metabolic reprogramming as a central function of the oncogenic miR-17∼92 miRNA cluster that drives the progression of MYC-dependent tumors.</AbstractText>
<CopyrightInformation>Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Izreig</LastName>
<ForeName>Said</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samborska</LastName>
<ForeName>Bozena</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Radia M</ForeName>
<Initials>RM</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sergushichev</LastName>
<ForeName>Alexey</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>ITMO University, St. Petersburg 197101, Russia; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Eric H</ForeName>
<Initials>EH</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lussier</LastName>
<ForeName>Carine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loginicheva</LastName>
<ForeName>Ekaterina</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Donayo</LastName>
<ForeName>Ariel O</ForeName>
<Initials>AO</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Poffenberger</LastName>
<ForeName>Maya C</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sagan</LastName>
<ForeName>Selena M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vincent</LastName>
<ForeName>Emma E</ForeName>
<Initials>EE</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Artyomov</LastName>
<ForeName>Maxim N</ForeName>
<Initials>MN</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duchaine</LastName>
<ForeName>Thomas F</ForeName>
<Initials>TF</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Russell G</ForeName>
<Initials>RG</Initials>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: russell.jones@mcgill.ca.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MOP-136915</GrantID>
<Agency>CIHR</Agency>
<Country>Canada</Country>
</Grant>
<Grant><GrantID>MOP-123352</GrantID>
<Agency>CIHR</Agency>
<Country>Canada</Country>
</Grant>
<Grant><GrantID>MOP-93799</GrantID>
<Agency>CIHR</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>08</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Cell Rep</MedlineTA>
<NlmUniqueID>101573691</NlmUniqueID>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C568997">MIRN17-92 microRNA, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C489427">MYC protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016271">Proto-Oncogene Proteins c-myc</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber>
<NameOfSubstance UI="C109790">STK11 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002471" MajorTopicYN="N">Cell Transformation, Neoplastic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015972" MajorTopicYN="Y">Gene Expression Regulation, Neoplastic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006019" MajorTopicYN="N">Glycolysis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064593" MajorTopicYN="N">Heterografts</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017710" MajorTopicYN="N">Lymphocyte Transfusion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008214" MajorTopicYN="N">Lymphocytes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008223" MajorTopicYN="N">Lymphoma</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D035683" MajorTopicYN="N">MicroRNAs</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010085" MajorTopicYN="N">Oxidative Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016271" MajorTopicYN="N">Proto-Oncogene Proteins c-myc</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>03</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>06</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>07</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>8</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>8</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>11</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27498867</ArticleId>
<ArticleId IdType="pii">S2211-1247(16)30954-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.celrep.2016.07.036</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Missouri (État)</li>
<li>Québec</li>
</region>
<settlement><li>Montréal</li>
<li>Saint-Louis (Missouri)</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université Washington de Saint-Louis</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Québec"><name sortKey="Izreig, Said" sort="Izreig, Said" uniqKey="Izreig S" first="Said" last="Izreig">Said Izreig</name>
</region>
<name sortKey="Donayo, Ariel O" sort="Donayo, Ariel O" uniqKey="Donayo A" first="Ariel O" last="Donayo">Ariel O. Donayo</name>
<name sortKey="Duchaine, Thomas F" sort="Duchaine, Thomas F" uniqKey="Duchaine T" first="Thomas F" last="Duchaine">Thomas F. Duchaine</name>
<name sortKey="Johnson, Radia M" sort="Johnson, Radia M" uniqKey="Johnson R" first="Radia M" last="Johnson">Radia M. Johnson</name>
<name sortKey="Jones, Russell G" sort="Jones, Russell G" uniqKey="Jones R" first="Russell G" last="Jones">Russell G. Jones</name>
<name sortKey="Lussier, Carine" sort="Lussier, Carine" uniqKey="Lussier C" first="Carine" last="Lussier">Carine Lussier</name>
<name sortKey="Ma, Eric H" sort="Ma, Eric H" uniqKey="Ma E" first="Eric H" last="Ma">Eric H. Ma</name>
<name sortKey="Poffenberger, Maya C" sort="Poffenberger, Maya C" uniqKey="Poffenberger M" first="Maya C" last="Poffenberger">Maya C. Poffenberger</name>
<name sortKey="Sagan, Selena M" sort="Sagan, Selena M" uniqKey="Sagan S" first="Selena M" last="Sagan">Selena M. Sagan</name>
<name sortKey="Samborska, Bozena" sort="Samborska, Bozena" uniqKey="Samborska B" first="Bozena" last="Samborska">Bozena Samborska</name>
<name sortKey="Vincent, Emma E" sort="Vincent, Emma E" uniqKey="Vincent E" first="Emma E" last="Vincent">Emma E. Vincent</name>
</country>
<country name="États-Unis"><region name="Missouri (État)"><name sortKey="Sergushichev, Alexey" sort="Sergushichev, Alexey" uniqKey="Sergushichev A" first="Alexey" last="Sergushichev">Alexey Sergushichev</name>
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<name sortKey="Artyomov, Maxim N" sort="Artyomov, Maxim N" uniqKey="Artyomov M" first="Maxim N" last="Artyomov">Maxim N. Artyomov</name>
<name sortKey="Loginicheva, Ekaterina" sort="Loginicheva, Ekaterina" uniqKey="Loginicheva E" first="Ekaterina" last="Loginicheva">Ekaterina Loginicheva</name>
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{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27498867
   |texte=   The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.
}}

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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.

Source :

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